Advanced Methods for Natural Product Drug Discovery in the Field of Nutraceuticals
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چکیده
منابع مشابه
Advanced methods for natural product drug discovery in the field of nutraceuticals.
Advances in analytical methods and bioassay development have helped to push forward the research in natural products. In plant extracts and nutraceuticals, bioactive compounds are part of a complex mixture. The development of high-resolution methods related to HPLC for both chemical and biological profiling has significantly increased the efficiency of classical bioactivity-guided fractionation...
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Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...
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Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in 2000, 2001, and 2002. There were 15 new nat...
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ژورنال
عنوان ژورنال: CHIMIA International Journal for Chemistry
سال: 2011
ISSN: 0009-4293
DOI: 10.2533/chimia.2011.400